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Abstract A hypercoagulable state leading to a high risk of a thrombotic event is one of the most common complications observed in -thalassemia/HbE disease, particularly in patients who have undergone a splenectomy

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However, this result is expected considering the very high activity of glutaredoxins as deglutathionylating enzymes and a decreased GSSR concentration neither excludes mechanism (ii) or (iii) from Fig

And while the redness and induration can look alarming, they typically resolve within 24 to 72 hours without intervention

Pairing glutathione with supporting nutrients like vitamin C and N-acetylcysteine can further enhance its results
