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The protective roles of folic acid in preventing diabetic retinopathy are potentially associated with suppressions on angiogenesis, inflammation, and oxidative stress

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Peroxynitrite is also involved in the pathogenesis of acute kidney injury induced by sepsis [61], I/R kidney injury [62], diabetic glomerular lesions [63], and lipopolysaccharide-induced renal dysfunction [64]

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Second, most study patients and all controls were women, which may have created bias with the gender effect