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Several studies have highlighted that chronic opioid therapy, particularly at higher doses, can paradoxically make patients more sensitive to paina condition known as opioid-induced hyperalgesia (OIH)

DOI: 10.3389/fphys.2016.00594 45

In contrast, GLP-1 injections regulate blood sugar and suppress appetite, making them highly effective for significant weight loss

For regulators, this marks a challenge

Lechartier and Cole, 2015)
