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This damage and deterioration causes wrinkles, sagging and changes in pigmentation
The authors proposed the following model of Se uptake to the brain via SELENOP-LRP8: SELENOP present in blood and CSF is taken up by LRP8-positive cells of BBB and BCB, resynthesized in neighboring astrocytes, and subsequently released to supply LRP8-positive neurons within the brain with Se Figure 2
R.KonzelmanC.GibsonS
Fitzsimmons, C
Yet, there remains uncertainty about the sequence and direction of events, i.e., which are upstream or downstream, and which may be hubs for intersecting spokes
