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However, excess glutamate levels suppressed hepatic glutamine synthetase activity, thereby impairing the ammonia detoxification capacity and inducing pathological hyperammonemia

[Google Scholar] Kirisattayakul, W

Alcohol, glucose metabolism and diabetes

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Another PI3K inhibitor LY294002 (20 M) had the similar results, indicating that PI3K contributes to IGF-1R mediated IA reduction[72]
