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10.1053/smrv.2001.0245 33 BoutagyN

Moreover, it was postulated that the aromatic ring of the 3-homotyrosine side chain and the C-terminal phenyl ring interact and Phe550 in IRAP further stabilizes aromatic/hydrophobic packing ( More recently, a crystal structure of IRAP with the macrocyclic peptide inhibitor 23 (HA08) was reported (Mpakali et al., 2020)

That difference is important: Water-soluble vitamins dissolve in water and generally are not stored in large amounts in the body

[DOI] [PubMed] [Google Scholar] 45.Bhatti J.S., Bhatti G.K., Reddy P.H

Preclinical studies have shown that cagrilintide is extensively metabolised and subsequently excreted as metabolites in bile and urine [data on file]