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Vitamin B12 blood levels of 200 picomoles per liter (pmol/L) or below are typically considered low, though diagnosing a true deficiency can be complicated ( If you worry you might be deficient, its best to consult a healthcare professional

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From a pathological perspective, the disease is characterized by the progressive degeneration of both upper motor neurons (UMN) in the cerebral cortex and lower motor neurons (LMN) in the brain stem and spinal cord