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Abnormalities in mitochondrial function, such as defects in the electron transport chain (ETC), oxidative phosphorylation (OXPHOS), and disturbances in ATP production and calcium levels, are considered major factors involved in the pathogenesis of these diseases [1,2,3]

doi: 10.1016/j.heliyon.2023.e16245

10.3389/fmolb.2022.901565 23 DasariS.Bernard TchounwouP

During aging, vital organs including the heart, liver, and kidneys undergo degenerative changes

Only small amounts of drug are released at a time, so potent drugs are better suited to this route of administration if systemic effects are required
