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As for the role that caffeine has in the purported benefits of the coffee enema, drinking coffee is a far more effective method for increasing the amount of caffeine in your blood (and hence causing vasodilation to potentially send toxins from the blood into the colon, or causing increased bile acid secretion to potentially facilitate liver detoxification) compared to administering it at the other end

Gaston J, Maestrali N, Lalle G, et al

It's found in our digestive systems including those of our canine companions

Conclusion Based on photographic records from standardized orthodontic treatment, results of this study showed that patients undergoing fixed orthodontic treatment have a significantly high risk of developing new WSL during orthodontic treatment