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Description
APS8 suppresses NSCLC tumor cell proliferation and triggers apoptotic signaling, with an IC50 of 375 nM for A549 cells and 362 nM for SkMES-1 cells, while showing no detectable impact on the MRC-5 lung fibroblast cell line [300]
KimballABJemecGBESayedCJKirbyJSPrensEIngramJRet al
The protective effects are mediated through upregulation of expression of TJ proteins (notably occludin and ZO-1)
It can, for example, carry out metabolic conversion pathways and utilize secretory systems that allow the excretion of potentially toxic compounds
Subsequent studies focused on the structural modification of 27 afforded a new synthetic triterpenoid inhibitor 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic acid imidazolide ( 28 ) [147]
