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The mechanism underlying thiol cytotoxicity is not entirely understood, but their oxidation in the presence of free Cu 2+ ions to produce toxic ROS was proposed as a plausible possibility 45,46,47,48,49,50

SantangeloLMarchettiACicchiniCConigliaroAContiBManconeCet alThe stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4alpha

We repeated this experiment using the HMG-CoA reductase inhibitor lovastatin, and we further validated our screen results by using commercially available drugs targeting enzymes on either side of the Cryptosporidium growth divide (Fig 2C)

The NADPH-dependent glutathione reductase (Gor) keeps GSH in its reduced state to maintain a high GSH/GSSG ratio ranging from 30:1 to 100:1 in the cytoplasm

cereale , and A