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The three primary compounds 78c, 1ai, and Iah have demonstrated specificity and potency in inhibiting CD38 and increasing intracellular NAD + when administered orally 22,52

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Simunkova M, Lauro P, Jomova K, Hudecova L, Danko M, Alwasel S, Alhazza IM, Rajcaniova S, Kozovska Z, Kucerova L, Moncol J, Svorc L, Valko M (2019b) Redox-cycling and intercalating properties of novel mixed copper(II) complexes with non-steroidal anti-inflammatory drugs tolfenamic, mefenamic and flufenamic acids and phenanthroline functionality: structure, SOD-mimetic activity, interaction with albumin, DNA damage study and anticancer activity

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In a study by Kang et al., postoperative pancreatobiliary cancer patients who followed a low-carbohydrate ketogenic diet (LCKD) for two weeks showed increased levels of total ketone concentration (-hydroxybutyrate + acetoacetate) and -hydroxybutyrate in their serum compared to patients on a general hospital diet