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Microbiota-Brain-Gut Axis Groundbreaking medical theories and practices in the 19th and early 20th centuries linked microbes to mood disorders.10 In the 1825 classic The Physiology of Taste , Jean-Anthelme Brillat-Savarin wrote: Digestion, of all the bodily functions, is the one which exercises the greatest influence on the mental state of the individual.11 Modifying diet, administering beneficial microbes such as Lactobacillus acidophilus in milk products, correcting dysbiosis, and ridding the body of intestinal toxemia were common medical interventions for individuals suffering from melancholia and the neuroses.12 Despite their promise and potential for healing illnesses of the nervous system, with the dawn of the antibiotic era, microbial-centric therapies were discarded as medical mythology