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Treatment typically involves vitamin B12 supplementation, either through oral supplements or injections, depending on the severity of the deficiency and underlying causes.

The combination of the amylin analogue pramlintide and the recombinant human leptin metreleptin caused significant weight reductions ( - 11.5kg) in comparison with monotherapy in a 24-week phase 2 clinical trial [248]

However, our bone marrow transplantation assay showed that CD38 deficiency in lymphocytes led to lack of protection against Ang II-induced vascular remodeling, suggesting that the effects of CD38 on Ang II-induced vascular remodeling might rely primarily on vascular smooth muscle cells (VSMCs), not lymphocytes

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