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Abstract The intestinal barrier is a complex structure that not only regulates the influx of luminal contents into the systemic circulation but is also involved in immune, microbial, and metabolic homeostasis

Both the immune system and the vascular system are essential for generating neurons and determining neuron viability (Vallon and Chang 2014)

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Beyond sleep, DSIP is investigated for its effects on stress adaptation, pain modulation, and neuroendocrine regulation, including potential interactions with cortisol, melatonin, and growth hormone pathways