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The levels of ROS maintained by an oxidant-antioxidant balance within each cell serves as important signaling molecules influencing cellular activities such as T cell activation, vasomotor tone, and normal gene expression (Kamata)

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These proteins are activated through a process involving vitamin K, which leads to calcium deposition in thebones and prevents arterial calcification

Reported doses vary, but typical oral supplementation ranges from 200 to 400 mg (IU) per day for 23 months

Support for a role of Mrp1 and Mrp2 in GSH export is provided by studies in knockout mouse models