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Severe vitamin B12 deficiency often manifests as colalamin-deficiency anemia, neuropathy and myelopathy

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Because anti-folates can interfere with the normal metabolic pathway of folates in the body, it might be reasonable to speculate that treatment with pemetrexed would alter folate metabolism and that this would be reflected by an elevation of plasma Hcy concentration
Vitamin B12, the way your body uses it
