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Description
The effects exceeded those of vitamin C and retinoic acid in comparative analysis

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doi: 10.1097/00005072-198509000-00003 82 ScheidtTAlkaOGonczarowska-JorgeHGruberWRathjeFDellAicaMet al
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

Higher concentrations aren't necessarily better and may increase irritation risk without proportional benefits