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Cyanocobalamin is indicated for vitamin B 12deficiencies due to malabsorption which may be associated with the following conditions: It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see Drug Interactions), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue

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A recent study revealed an increase in circulating CD38 + lymphocytes and the proportion of circulating CD38 + plasmablasts and plasma cells in SSc 23