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The Institute of Medicine did not establish a tolerable upper intake level (UL) for Cys or Met intake because data were insufficient for dose-response assessment and derivation of a UL for healthy adults

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Also, individual patient data meta-analysis showed that severe OSA is independently linked with an increased endothelial dysfunction (31)

Conclusion This article systematically reviews the management of AE, addressing first-, second-, and third-line therapies, with special emphasis on innovative drugs for resistant AE

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