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The interaction between interleukin-22 and interleukin-17 inhibits keratinocyte differentiation while increasing their proliferation and motility, leading to nuclear retention within the stratum corneum, epidermal hyperplasia (acanthosis), and elongation of the epidermal rete ridges (papillomatosis) all of which are characterized by psoriatic skin plaques (Becher and Pantelyushin 2012)
Consult a healthcare provider before use if you are taking chronic medication or have any underlying health conditions
Renal fibrosis starts with pericyte differentiation into active myofibroblasts in the interstitium layer due to hypoxia [129]
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