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Study design: Prospective observational cohort study

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Strongly influenced are again the active center and the subsequent 2 helix (F25 to E41)
Additionally, Nrf2 overactivation in hepatoma cells inhibits the pro-inflammatory response by suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, creating a favorable environment for malignant cell survival and protecting them from oxidative stress [138]
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