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Thus, Gsr-mediated redox regulation is crucial for fungal clearance by neutrophils and the proper control of the inflammatory response by macrophages during host defense against fungal challenge

Inhibitors of this system, such as Erastin, drastically reduce intracellular GSH levelsby over 80%thereby impairing GPX4 function and triggering ferroptosis (Ayton et al., 2017)

This can result in temporary sensory and perceptual disturbances as well as permanent structural damage to the nervous system

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Many individuals with hypothyroidism experience weight gain as a symptom of their condition, even when taking levothyroxine