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for major depressive disorder, its clinical story is mixed: the Phase II trials primary depression endpoint was not met

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Its mechanisms of action include inhibition of pain peptide release from nerve terminals and sensory ganglia, anti-inflammatory and antiglutaminergic effects, and reduction of sympathetic neural discharge

While lipo B12 injections are very safe for most people, its best to consult a doctor before starting injections, especially if you: Have a personal or family history of autoimmune disorders Have methylmalonic acidemia or other B12-related genetic disorders Are you pregnant or breastfeeding Have kidney disease or liver disease Have leukaemia or other blood disorders Have had allergic reactions to B12 supplements before In these cases, your doctor can determine if injections are suitable or an alternative treatment is better