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Allergic reactions are rare but documented

By delivering vitamin B12 straight into your muscle tissue, your body can use 100% of the dose immediately

10.1016/j.tips.2010.09.005 Trends Pharmacol

Your thyroid helps to regulate important aspects of intestinal function including intestinal motility (how frequently your bowels are moving) and how much acid your stomach produces (via their impact on specific cells in the stomach)
