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To note, Treg cells require a functional mitochondrial complex III to maintain their suppressive function, suggesting a fascinating role of mROS in the metabolic and epigenetic landscape of Treg cell compartment (47)
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[DOI] [PubMed] [Google Scholar] Tortella G
Nano Lett 17:63306334 Jin R (2015) Atomically precise metal nanoclusters: stable sizes and optical properties
This reinforces the need for carefully titrated regimens, especially in clinical settings where circadian timing (chronopharmacology) may dictate efficacy
