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Same issue with me
It was crude but powerful

In animal studies, this effect resulted in lower body weight without changes in blood sugar or IGF-1 levels

Coskun and colleagues (Cell Metabolism, 2022) provided the foundational characterisation, demonstrating that balanced engagement of all three receptors produces metabolic effects not achievable through dual or single-receptor pharmacology alone

doi: 10.1016/s0140-6736(77)91940-7
