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Under basal conditions, NRF2 is tightly regulated by Kelch-like ECH-associated protein 1 (KEAP1), a repressor protein that mediates the degradation of NRF2 by the ubiquitinproteasome pathway
A synapse enriched in Neto1-associated KARs would be poised to faithfully follow high-frequency inputs
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The latter suppress protein biosynthesis and contribute to the development of hemolytic uremic syndrome, which is a life-threatening complication
Cortisol in humans, and corticosterone in rodents, hold central importance for the bodys response to stress by promoting energy mobilization
