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Perhaps this has to do with the specific discrete mutational event causing their development

Various clinical and in vivo studies have been undertaken to evaluate the effects of foods and food-derived components on the activity of detoxification pathways, including phase I cytochrome P450 enzymes, phase II conjugation enzymes, Nrf2 signaling, and metallothionein

Childhood hearing is associated with growth rates in infancy and adolescence

Hoskin DW, Ramamoorthy A

Verdure and Goldberg found "a tenfold increase in relative risk was associated with cholesterol less than 3.4 mmol/l, and the least risk was associated with the middle tertile of cholesterol levels (4.0-5.0 mmol/l)." 3.4 mmol/l equals 131.3 ml/dl which is not really extreme