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A main goal for future treatments must be to lower IOP together with the protection from pressure-dependent inflammation and neurodegeneration, an approach that may include direct targeting of the pressure sensing proteins themselves

Quercetin, a flavonoid widely distributed in nature, has been verified to decrease the risk of type 2 DM according to epidemiological investigations[180], and its mechanism is extensive, including antioxidant, anti-inflammatory and anti-fibrotic effects

doi: 10.1038/s41574-020-00451-4 60 AliTKAl-GayyarMMMatragoonSPillaiBAAbdelsaidMANussbaumJJet al

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Moreover, membrane cholesterol is required for DC antigen presentation and their capacity to promote pathogen clearance (45, 63)