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More serious side effects of Accutane include: Inflammatory bowel diseases, such as Crohns disease or ulcerative colitis Mental health problems, including psychosis, new or worsening depression, or suicidal thoughts Erectile dysfunction and loss of libido Changes in blood sugar, triglycerides, or cholesterol Pancreas inflammation Headaches Nervous system changes, such as drowsiness, dizziness, or blurred vision Accutane has been shown to increase the risk of birth defects, including premature birth, and physical malformities

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