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Iron is essential for metabolic activity in all living organisms due to its catalytic role
Similarly, ROS-mediated HIF-1 activation has been found in ox-LDL-stimulated macrophages [113], indicating that HIF-1 activation is jointly regulated by multiple factors such as lipids and hypoxia in plaques
It should be noted that a recent study found that sorafenib was not a bona fide inducer of ferroptosis based on screening results using a panel of cancer cell lines [98]
Although EMA401 showed anti-neuropathic properties in painful diabetic neuropathy and postherpetic neuralgia patient populations, these trials were terminated or withdrawn due to the observed side effects of EMA401 [93, 94, 126, 127]
