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This is associated with swelling of the axon and formation of axonal spheroids

doi: 10.1016/j.jaad.2014.05.019
Markowitsch SD, Schupp P, Lauckner J, Vakhrusheva O, Slade KS, Mager R

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With more studies directed to reveal how genetics, environmental, autoimmune, and physiological are orchestrated in the pathogenesis of PSC, the goal for early diagnosis, adequate follow-up, treatment, and malignant tumor screening, deciphering the specific pathogenic pathways, defining potential therapeutic targets, and effective therapies will be at hand
