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In the same species, BB increased GH release and inhibits the expression of somatostatin (123, 124), and it has been postulated that the actions of BB in the regulation of GH in these species could be mediated by somatostatin ( Ghrelin Ghrelin was originally reported in 1999 (247), as the first and only known endogenous ligand of the growth hormone secretagogue receptor 1a (GHSR1a) (248)

IGF-1 exerts its biological effect through binding to the IGF1 receptor (IGF1R), its effect is modulated through interaction with a group of binding proteins (IGFBPs), which tend to inhibit the effect of IGF-1 [2]

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J., & Gil-Bea, F

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