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At present, there is no evidence to support a different recommended intake of choline from that of younger adults (425 mg/day for women and 550 mg/day for men)

4.1 Betaine in hyperhomocysteinemia The elevated plasma total homocysteine (i.e., hyperhomocysteinemia) is a known risk factor for CVDs (Refsum et al., 1998) and is also associated with some neurological disorders (Hasan et al., 2019)

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Research has indicated that dietary choices, particularly high-fat diets, significantly influence the gut microbiota, exacerbating DED symptoms through mechanisms such as decreased tear secretion, increased oxidative stress, and heightened apoptosis (Wu et al., 2020)