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Genetic predisposition towards sarcoidosis is mostly linked to the HLA-encoding genes within the major histocompatibility complex (MHC) situated on chromosome 6 [42]
The follicular pattern appears most frequently, usually involving the smaller airways
FDA nonclinical toxicology review (2023-2024) flagged DNA damage in pituitary cells and injection-site necrosis in animal studies, plus immunogenicity and impurity risks from compounded material, alongside GH/IGF-1-axis effects such as fluid retention, joint discomfort, flushing, and headache reported by users
