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5-Amino-1MQ acts as a competitive inhibitor with respect to the nicotinamide substrate (submicromolar IC50), increasing the intracellular nicotinamide available for NAD+ salvage via NAMPT - which is then studied for downstream effects on NAD+-dependent sirtuins and mitochondrial function

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Research 2

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Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia