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When multiple K i values for the same enzyme and metabolite were present, we used their geometric mean

[DOI] [PubMed] [Google Scholar] 82.Sinyeue C, Matsui M, Oelgemller M, et al

In this context, Richelson (2013) point out that the limited therapeutic effectiveness of antidepressant treatments may stem from several factors, such as the delay between drug administration and clinical improvement, which occurs even when effective plasma concentrations are reached

Western Blot HepG2 cells were homogenized on ice with RIPA buffer supplemented with phosphatase and protease inhibitors (Pierce, Thermo Scientific, MA, USA)