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The synthetic triterpenoid CDDO-Me blocks survival of neoplastic mast cells and synergizes with KIT D816V-targeting drugs in inducing growth inhibition

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As expected, tha1 loss-of function mutants show up to 20 times higher Thr level ( tha2 mutant alleles are lethal presumably due to a very high Thr level ( O-METHYLTHREONINE RESISTANT 1 ( OMR1 ) gene ( tha1tha2 mutants achieved by OMR1 overexpression, A

In a separate report, Chen et al

Impact of loss-of-function mutations at the RNF43 locus on colorectal cancer development and progression