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Notably, c-MET is initially expressed as a 150 kDa single-chain precursor, which then turns into the mature form through the proteolytic cleavage between Arg307 and Ser308 by the furin protease 8

Chronic perfusion of angiotensin II causes cognitive dysfunctions and anxiety in mice

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Aging Cell 6 , 453470 (2007)

Crucially, specific gut bacteria directly influence thyroid hormone metabolism through intrinsic enzymatic activities, such as bacterial deiodinase-like enzymes
