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Still produces systemic effects

Yes, though most are mild and temporary

The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

Most people are unbothered by injectables, says Israetel, who also points out that people already are comfortable taking stuff they buy at Whole Foods that isnt approvedthey just dont care

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