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The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43
Meta-analyses suggest modest benefits, especially in older or heavier adults
For example, in cultured endothelial cells, lipoic acid was found to inhibit IKK-, an enzyme that promotes the translocation of redox-sensitive and pro-inflammatory transcription factor, nuclear factor-kappa B (NFB) from the cytosol to the nucleus (46)
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