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doi: 10.1186/s12969-018-0255-8

Concentrations of NNK in the saliva of women who used snuff ranged from 2.1 to 201 ng/g

Importantly, the authors of this work similarly did not interpret their findings related to cerebrovascular resistance as negative adaptations to RT, but instead consider the increase to be a protective response to reduce the effects of increased mean arterial pressure on the cerebral circulation - where hyperperfusion can damage the microvasculature (Thomas et al., 2021)

Additionally, while several studies have identified key pathogenic mechanisms underlying biliary, alcoholic, and HTG-related AP, most investigations remain focused on isolated signaling pathways or specific cellular subsets