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References Teichman SL, et al

Neuroinflammation (described in KE188) may lead to alteration of differentiation (partially described in KE1560), which could be linked to dysregulation of critical neuronal-, glia- and NSC-related gene expression, as suggested by downregulation of PAX6, TH, NR4A2, SLC18A3, OLIG1 and UTS2 , and the upregulation of GABRA3, MBP, GASK1B and HEY1

This is because active folate (methylfolate) is required for B12-dependent reactions, and MTHFR variants can reduce folate availability

However, none of the cytokines influenced PD-1 expression on CIK cells (Fig
