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Flavonoids, such as quercetin and catechins, are known for their ability to scavenge free radicals and modulate oxidative stress pathways [195]

These safety findings were crucial for advancing it into efficacy trials focused on weight loss

Silencing GPX3 essentially nullifies the antioxidant effects of TZDs, indicating that the PPAR-dependent antioxidant effects of these drugs are mediated through GPX3 [39]

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This deficiency can lead to megaloblastic anemia, where the body produces large, abnormal red blood cells that cannot function effectively, resulting in symptoms such as fatigue, weakness, and neurological issues