non melanotic melanoma Amelanotic Melanoma: It Doesn't Look Like Other Melanomas Non-melanoma skin cancer 'raises malignancy

Early studies suggest a benefit, but more studies are needed before the association is fully understood

Nat Biotechnol (2012) 30(4):2956

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5, (tie) Turtle Powell, Stephenville, Texas, and Dakota Kirchenschlager, Morgan Mill, Texas

When the pentamer binds to an activated lipid membrane, initially using its calcium-dependent binding specificity for ligands expressing phosphocholine, biochemical forces lead to its dissociation, inducing structural rearrangements that expose a cryptic binding site on the dissociated CRP monomers for cholesterol molecules found in lipid rafts [35,65]