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Although Tregs are not directly involved in the immune response to foreign antigens, they are necessary for maintaining immune tolerance to autoantigens and immune homeostasis in vivo

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In the regression analysis results (see Table 6, dopamine metabolites, such as homovanillate (HVA) and various dopamine sulfates, rank highest among the metabolite features for predicting MDS-UPDRS III total motor scores, indicated by the lowest sum-of-ranks across the performance metrics for both linear and radial SVM regression models (a complete ranking table, including scores for unidentified metabolites, is provided in Supplementary Table 12)

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