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It should be noted that accumulation of phytanic acid is not solely the result of defects in PhyH

Meanwhile, as only one RCT [11] on HIV-associated neuropathy was reviewed, limitations of the trial itself such as the low dose and short follow up period might also contribute to the inefficacy

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2 Methods Identification of supporting evidence for this narrative review, using structured literature searching of the PubMed database and ad hoc online searches, was conducted on 18 July 2024

This drug can also have possible negative side effects, such as liver dysfunction, vasospasm, and pulmonary stenosis, so further studies have not been done