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They are widely employed as vehicles for delivering a range of therapeutic agents such as antibodies, nucleic acids, chemotherapeutic drugs, etc

doi: 10.1016/0968-0004(88)90148-X

Controlled-release formulations have been discouraged in older adults due to the possibility of prolonged melatonin levels and unknown implications thereof [273]
Tirzepatide represents the larger expense

HF, heart failure
