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doi: 10.1007/s10096-015-2490-y, 99 XuP.MageswaranU

Zeng Z, Lu H, Wang RY, Liu W, Chen J, Benton CB, Baggerly KA, Shpall E, Champlin R, Konopleva M, Andreeff M

M1 macrophages are characterized by high inducible nitric oxide synthase (iNOS) expression and the secretion of pro-inflammatory factors, whereas M2 macrophages express molecules such as arginase-1 (Arg1) and interleukin-10 (IL-10) and participate in tissue repair ( in vivo do not exist as fixed binary states, but rather display a continuum of functions shaped jointly by microenvironmental signals, metabolic reprogramming, and epigenetic regulation ( In recent years, studies of immunometabolism have gradually revealed the important role of metabolic reprogramming in regulating immune cell function
The slides were then placed under running water for 10 minutes in glass jar and treated with 1% HCl and 1% ammonia water

Inflammatory cytokines induce nitric oxide (NO) and ROS production for innate immune cells and microglial cells
